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Dear all, I have a question regarding the best way to create a grey matter mask of the pre-frontal cortex (PFC;including dorsal/ventral/medial/orbital areas), to be used as a pre-threshold mask in a group level analyzes, in order to limit the extent of multiple comparisons corrections given I have a-priori hypothesis concerning the PFC only. I have never done this before, and while trying to find the answer to this looking at the documentation online, I have so far found what I think are two different potential approaches: 1) Based on an anatomical (or functional) image, to use fslmaths to define the coordinates that would create a mask extracting the brain area of interest (in this case, PFC), like this: fslmaths T1High_brain -roi x (#slices) y (#slices) z (#slices) 0 1 PFC_mask But, this does not seem to be a very practical way to avoid including white matter in the mask. 2)Based on pre-defined ROI masks, such as the ones found here: $FSLDIR/data/atlases/HarvardOxford-Cortical.xml run some type of "concatenate" command that would create a PFC mask containing all the cortical PFC ROIs. Since I am new to this, it is very possible that neither of the two approaches above are ideal. I would highly appreciate your feedback regarding how one could best go about this (whether it is one of the ways delineated above, or some other way that I don't know about yet). Thank you very much in advance for your input! Regina