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Hi Moran It has been shown that a two points measurements (where each point is averaged several times) leads to more accurate measures of the ADC than multiple points with less averages. (see e.g. Eis and Hoehn-Berkage JMR 95 / Jones et al. MRM 99). Obviously, if you want to model multiple compartments with different ADCs, or restriction etc., then you will need more than two bvalues, but these models are not (yet) available in FSL. Cheers, Saad. On 28 Apr 2009, at 06:37, Moran Artzi wrote: > Hi, > A question regarding DTI analysis- > Is there any fit for analyze data with moor then one b value (3 or 4 > points all > in b value below then 1200)? > Many thanks > Moran > Saad Jbabdi Oxford University FMRIB Centre JR Hospital, Headington, OX3 9DU, UK +44 (0) 1865 222545 (fax 717) www.fmrib.ox.ac.uk/~saad