Hi, Can you let me know which version of fsl you are using and the contents of your design.con and design.mat files? Many Regards Matthew > Hello list, > > I've just run a multiple regression with tbss on some skeletonised > FA data in a single group of subjects using 3 EVs - age, 1 target > behavioural variable and 1 potentially confounding behavioural > measure. I created a design matrix with the 3 normalised EVs, and > orthogonalised the target EV with respect to age and the confounding > EV. I assumed this would show me the changes in FA attributable to > the target EV with the other 2 covaried out. This was using > randomise and the TFCE option. When I display the > tbss_tfce_corrp_tstat contrast image in fslview with the -b 0.95,1 > threshold, most of the skeletonised data appears to correlate with > the target variable. This is the case even when I use a more > conservative 0.99,1 threshold. > > I found this a little surprising, so ran the same design again > without orthogonalising the target EV. The results were virtually > the same. > > So I guess the question is, have I done anything wrong here? > > thanks in advance, > > Greig > > > > -- > Dr Greig de Zubicaray | fMRI Laboratory > Centre for Magnetic Resonance | University of Queensland | > Brisbane, QLD 4072 | AUSTRALIA > Phone: +61-7-3365-4250 (direct) | +61-7-3365-4100 > (reception) | Fax: +61-7-3365-3833 > Email: [log in to unmask] | Web: http://www.fmrilab.net/ > CRICOS Provider Number 00025B >