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Have any other Windows users noticed that Refmac5 runs much slower on the same job when you upgrade from CCP4 6.0.2 to 6.1.1? Best regards, Phil Leonard. -- "DISCLAIMER: This e-mail and any attachments are confidential. They may contain privileged information and are intended for the named addressee(s) only. If you are not the named addressee do not disseminate, distribute, copy or retain this e-mail, or any part of it, in any manner. Please notify the sender immediately if you have received this e-mail by mistake and delete it from your system. The sender does not accept any liability for any errors or omissions in the contents of this message, which arise as a result of e-mail transmission. Unless expressly stated, opinions in this e-mail are those of the individual sender, and not of Galapagos NV or any of its subsidiaries including BioFocus DPI. Galapagos NV and its subsidiaries including BioFocus DPI reserve the right to monitor all e-mail communications through its network. Although this e-mail has been scanned for all known viruses, the sender does not guarantee that this message is virus-free and disclaims any liability for viruses that may be transmitted with this message."