Mark, Thank you for your reply. I do have a another question though. If the method I had originally tried was correct, then why was the post-stats section of the log empty and why were there no cope directories created? I also seem to remember there were quite a few errors in the log, but I'd have to re-run it to show you since these results directories were deleted. Running the group comparisons at the 2nd level (for a motor task), yielded cope directories, but no significant differences at Z=3.0, which I find somewhat odd given that the group results, upon visual inspection, appear significantly different. I will try at a lower Z, but I have a feeling the results will also be empty. The log file has many of the following lines: WARNING: The passed in varcope file, tmpvarcope0027, contains voxels inside the mask with zero (or negative) values. These voxels will be excluded from the analysis. nevs=2 ntpts=20 ngs=2 nvoxels=4842 Running: nmaskvoxels=4842 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 nmaskvoxels=4842 Is this normal? Thanks.