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Hi, Not sure what you mean by intensity normalisation - do you mean adjust the global intensity range, or do you mean bias field correction? If you mean the latter, then that is done as part of running FAST segmentation, which requires BET to have been run, but not spatial normalisation. Steve. On 14 Feb 2009, at 02:30, WangPing wrote: > dear list, > > Does intensity normalization have to require spatical registraion > first? For example I have a group of T1 volumes (skull stripped), > can I do intensity normalization on them directly (without spatial > normalization)? In other words, is intensity normalization > independent of spatial normalization? Sorry I do not know the > principle of intensity normalization. > > Best, > Ping > > 使用新一代 Windows Live Messenger 轻松交流和共享！ 立刻下载！ --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------