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Only if it makes logical sense to do so for purposes of contrast sign interpretation, or to reduce voxel search space. Cheers -------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford. OX3 9 DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------- On 20 Feb 2009, at 15:38, Vishwadeep Ahluwalia <[log in to unmask]> wrote: > Do i need to mask each differential contrast with the mean contrast > in the > 2nd level design?(in which case i'll include the mean contrast in > the design > as well) > -vish >