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The protein wolves get it - and it's never heard from or seen again. Artem --- When the Weasel comes to give New Year's greetings to the Chickens no good intentions are in his mind. -----Original Message----- From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jacob Keller Sent: Wednesday, February 25, 2009 4:04 PM To: [log in to unmask] Subject: Re: [ccp4bb] protein folds What happens when a single protein strays from the fold? Jacob ----- Original Message ----- From: "Edward A. Berry" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, February 25, 2009 2:48 PM Subject: Re: [ccp4bb] protein folds > As an outsider to this field, it would seem another way to approach it > would be to ask, of the currently known folds, how many have only one > member (excluding evolutionarily related protein families)? > > If a large number of folds have only been sampled once, it is likely > that there are others that have not been sampled at all. If every known > fold has at least 5 independently-evolved examples solved, then it is > less likely that some have been missed. > > If at this stage there are still many folds with only one known example, > then probably in fact many folds are represented by a single protein > family, in which case it will be necessary to solve a representative from > every family to be sure we're not missing a fold. > > > Paul Emsley wrote: >> Jayashankar wrote: >>> Dear Folks, >> >> Dear gmail-user, >> >>> >>> The last novel proteins fold were from the yr 2007(pdb statistics), >>> From 2007 to till date no novel fold has been identified, this mean >>> the present 1283 fold are the final or >>> should I wait, if so , with what criteria do I expect for a new >>> fold..or what are the expectations ... [snip] >> >> >> Here's an experiment: >> >> Find a blindfold and put it on. Oh, but before you do that, take a >> map of England and place it on a dartboard. >> >> Now take 56066 darts and throw them at the map on the board. >> >> Take off the blindfold and investigate where the darts hit. Did you >> hit all the towns and cities? You hit London, Birmingham and Leeds >> almost certainly. But what about Brighton, did you get that? How >> about Clitheroe, was that hit? (Does Clitheroe count anyway or is >> that just another part of Preston?) >> >> I hope that that provides you some with insight. >> >> Paul. >> >