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All Single isomorphous replacement with anomalous scattering uses two datasets that are isomorphous while using the anomalous signal in one (here scattering and dispersion are synonymous?). How does SIRAS use the anomalous scattering signal that's different than a single wavelength anomalous dispersion ? How does an anomalous difference patterson (SAD) differ from an isomorphous difference patterson with anomalous scattering (presumably utilizing a native crystal)? Can a dataset that was not resolved by MAD/SAD be resolved by MIRAS/ SIRAS provided a good native dataset is available (Does MIRAS/SIRAS offer more phasing power than a typical SAD dataset?) Any input would be appreciated! FR --------------------------------------------- Francis Reyes M.Sc. 215 UCB University of Colorado at Boulder gpg --keyserver pgp.mit.edu --recv-keys 67BA8D5D 8AE2 F2F4 90F7 9640 28BC 686F 78FD 6669 67BA 8D5D