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Rose, Well you could remind your obstetrician that prolactin is the only pituitary hormone which is under inhibitory control from the hypothalamus and that in general the problem is thought of the other way around - i.e. the difficulty of obtaining a normal, basal low PRL result, since the patients are usually under stress and that pushes the PRL level up. From your address you appear to be in Quebec where human prolactin was first isolated and described! I did quite a bit of work in the 1970's looking at sequential human prolactin samples, both from unstressed and stressed patients (CAPST - combined anterior pituitary stimulation test). The prolactin results from such exercises yielded no additional information over thre basal samples, although you will find some very hopeful publications from the period which don't agree with this conclusion. Possibly the consultant in question has been reading some of this older literature. Nick Miller London 2009/2/26 Rose Djiana <[log in to unmask]>: > Hi, > Would you please refer me to litteraure, or share your knowlegde about the > use of serial prolactin measurements (blood drawn at 0, 20, and 40 min) > in the workup of patient with infertility? One of our G-Obstetricians use > that test based on the argument that the pulsatile secretion of prolactin > cause important variation prolactin, so that the basal level of patient is > better captured by this "tripple" prolactin. According to him, some > hyperprolactinemic patient are missed > by a regular (standard) prolactin test. > > Your help is appreciated. > > Kind regards. > > Rose > > ------ACB discussion List Information-------- > This is an open discussion list for the academic and clinical > community working in clinical biochemistry. > Please note, archived messages are public and can be viewed > via the internet. Views expressed are those of the individual and > they are responsible for all message content. > ACB Web Site > http://www.acb.org.uk > List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html > List Instructions (How to leave etc.) > http://www.jiscmail.ac.uk/ > ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/