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Thanks very much John. That, in fact, was A problem. I used coreg reslice on the second image so that both images now have a negative x voxel size and are stored in RPI order. Unfortunately the same error in HDW still occurs. Any other ideas? Cheers, Kris On Wed, 7 Jan 2009 19:39:40 +0100, John Ashburner <[log in to unmask]> wrote: >My best guess is that one of the images is stored left-handed, but the other >is stored right-handed. If you display an image, does one have a negative x >voxel size, but the other not? > >Best regards, >-John > > >On Wednesday 07 January 2009 18:31, Kristopher Kosmatka wrote: >> I have been encountering an error with high dimensional warping, I hope >someone may know a solution. I have two grey matter segment images that have >been previously rigidly coregistered. The images are unsigned INT data type, >256x124x256 voxels. Nothing is unusual that I can see about the images. I >am running SPM5 revision 1782, in MATLAB 7.7, on x84_64 machine running >Scientific Linux (An enterprise Red Hat clone). The symptoms: All default >settings were used in the HDW setup. The HDW begins and prints the following >to standard output: >> >> -------------------------- >> >> Running "High-Dimensional Warping" >> Generating uniform affine transformation field >> Warping (iterations=8 regularisation=4) >> 193.63152 >> nan >> XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX... >> >> >> This is followed by many X's ad infinitum. I've allowed this to continue >> running for 15-20 minutes and it just continues like this without ever >> finishing the job. Recompiling the mex files in my SPM distribution using >> the makefile in src failed to fix the problem. Has anyone encountered this >> problem, any ideas? >> >> Many thanks, >> Kris >> >> >> Kristopher J. Kosmatka >> Research Specialist >> Johnson Neuroimaging Lab >> University of Wisconsin - Madison >> Wm. S. Middleton Memorial VA Hospital - GRECC