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It's a vector containing the mean FA value for each subject. Julie E. McEntee, M.A., C.C.R.P. Senior Research Program Coordinator Department of Psychiatry- Neuroimaging Johns Hopkins University School of Medicine 600 N. Wolfe St./ Phipps 300 Baltimore, MD 21287 Phone: 410-502-0468 Fax: 410-614-3676 ----- Original Message ----- From: "MCLAREN, Donald" <[log in to unmask]> Date: Monday, January 5, 2009 11:50 am Subject: Re: [SPM] fMRI 2nd-level analysis with covariates To: Julie E McEntee <[log in to unmask]> > Is the covariate of interest the FA value extracted from a region or > the FA > value at each voxel? > > On Mon, Jan 5, 2009 at 10:38 AM, Julie E McEntee <[log in to unmask]> > wrote: > > > Hello SPMers, > > > > I am using the latest version/update of SPM5 with MatLab 7.0 on > Windows XP > > Professional 2002, service pack 3. > > > > I have 1st-level analyses (.con hdr/image files) consisting of the > > difference between 2 task conditions for each of 2 groups (patients > and > > controls). > > > > There is a statistically significant difference between the 2 > groups in > > years of education. I would like to include this as a "nuisance" > variable at > > 2nd-level analysis. I would also like to include a "covariate of interest" > > (in this case fractional anisotrophy- FA). There is no correlation > between > > these 2 variables. > > > > What test should I use at the 2nd-level (and subsequent definition > of > > contrast weights) to answer the queston: > > > > Is FA related to the difference in BOLD response between groups? > > > > Thank-you for your help, > > > > Julie > > > > Julie E. McEntee, M.A., C.C.R.P. > > Senior Research Program Coordinator > > Department of Psychiatry- Neuroimaging > > Johns Hopkins University School of Medicine > > 600 N. Wolfe St./ Phipps 300 > > Baltimore, MD 21287 > > Phone: 410-502-0468 > > Fax: 410-614-3676 > > > > > > -- > Best Regards, Donald McLaren > ===================== > D.G. McLaren > University of Wisconsin - Madison > Neuroscience Training Program > Office: (608) 265-9672 > Lab: (608) 256-1901 ext 12914 > ===================== > This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED > HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is > intended only for the use of the individual or entity named above. If > the > reader of the e-mail is not the intended recipient or the employee or > agent > responsible for delivering it to the intended recipient, you are hereby > notified that you are in possession of confidential and privileged > information. Any unauthorized use, disclosure, copying or the taking > of any > action in reliance on the contents of this information is strictly > prohibited and may be unlawful. If you have received this e-mail > unintentionally, please immediately notify the sender via telephone > at (608) > 265-9672 or email.