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Hi Kristen, The old two-mask-symmetric mode is equivalent to the first option that you are describing, i.e. "multiple masks" with masks 1 and 2. Cheers, Saad. On 14 Jan 2009, at 19:23, Lindgren, Kristen, Ann wrote: > Hello. Way back when in an older version of FSL, I had been using > “Two masks –symmetric” in probtrack to identify pathways common to > the two masks (ie. only want paths that go through both masks). Now > that I’m using probtrackx, I just want to make sure that I’m picking > the right options. Do I just want to pick “multiple masks,” enter > the masks 1 and 2 or do I need to run “single mask,” enter mask 1, > and then enter mask 2 under waypoints masks? Or is there something > else I should be doing? Thanks! > > Kristen Saad Jbabdi Oxford University FMRIB Centre JR Hospital, Headington, OX3 9DU, UK +44 (0) 1865 222545 (fax 717) www.fmrib.ox.ac.uk/~saad