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Could Lyne in the ME poem Ichot a burde in a bour (or Annote and Iohon, in the Harley Lyrics; 13th century) be an n-variant of Lyme? The line is:
33: Such licoris mai leche from Lyne to Lone;
Traditionally this is the river Lyn in Dorset, but we really expect something in the north-west, and Wirral has just been mentioned in line 27, so a district name is possible (Lone is the Lune). I don't think this was mentioned by Richard Coates in his article on Lyme in JEPNS, 36 (2003-4), 39-50.
Keith
PS: facsimile at http://www.soton.ac.uk/~wpwt/harl2253/ichot/ichotms.htm