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hi yes this may happen in some circumstances....have a look at J Am Chem Soc. 2008 Oct 15;130(41):13514-5. > Hi, > > I had a question about flexibility in ligand binding in an enzyme active > site. Is it possible for a substrate/product analogue to bind in more > than > one conformation in the active site. Since the ligand/enzyme interactions > are very specific I am a little confused about this. > Also which program would you use if you have to refine with alternate > ligand > conformation. > Please mention if you have ever come across any paper that explains such a > phenomena. > Thanks a lot. > > Mariah > -- > Mariah Jones > Department of Biochemistry > University of Florida >