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Hello, After several years of offering the molecular biology software VectorNTI free to the academic community (their "open access program") and building up a huge user base, Invitrogen have suddenly announced that they will no longer renew these free licences and the existing ones will be left to expire within the year. There are heavy renewal fees for anyone wishing to continue use of this software. Can anyone recommend decent alternative PC compatible alternatives? Main uses are construct and primer design, plus simple quick alignments, sequence data analysis etc. The database structure for storing sequences was pretty useful also. Ideally free, otherwise reasonably priced. I've seen CLCbio and Geneious have products, both free and paid. Any experience? Thanks, Darren EMBL Grenoble ps anyone using VNTI might consider a backup of their work by exporting files to .gb format. I don't know if a locked up (expired) version permits this and you will have no notice that it is about to expire.