In the ‘old’ days (late’70s) we used to measure digitoxin using the digoxin immunoassay.  That was in Guildford and if my memory serves me right, we used an in house method, where the antibody cross reacted to an extent with digitoxin (and other cardiac glycosides).  Of course you had to use digitoxin standards, but it gave reasonable results.  Of course the ‘target’ range for digitoxin is on a magnitude greater than that of digoxin, and of course it is less affected by renal function, since it is largely metabolised by the liver.

 

Graham

 

 

 

Hi

 

We have a patient on digitoxin with poor renal function, and the clinicians would like to measure the blood concentration. Do any of you have an assay for TDM digitoxin levels to which we could send samples, or know of one?

 

Regards

Steve

 

 

(apologies for any duplication- have tried a few times to access mail-base)

 

 

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Dr Stephen Frost, MSc, PhD, FRCPath, MCB, CChem, MRSC

Principal Clinical Scientist

Department of Clinical Biochemistry and Immunology

Brighton and Sussex University Hospitals NHS Trust

The Princess Royal Hospital

Lewes Road

Haywards Heath

West Sussex

RH16 4EX

 

Tel 01444 441881 ext 8197

Fax 01444 414051

email [log in to unmask]

 

Views expressed  are my own and not necessarily those of the Trust.