Richard,
We actually use 0.05 ug/L as the cut off for detecting myocardial damage (not classical MI cut off) on the Advia Centaur TnI ultra assay. As myocardial damage can be of varying aetiology ischaemic & non-ischaemic, we leave it to the clinicians to decide if the myocardial damage is due to acute coronary ischaemia or due to some other causes.
David's original statement is probably related to a recent NEQAS interpretative comment.
Best wishes
Mohammad
________________________________
From: Mainwaring-Burton Richard (RGZ) <[log in to unmask]>
To: [log in to unmask]
Sent: Monday, 1 December, 2008 15:34:36
Subject: Re: Troponin I - quoted cut-off value 0.10 ug/L
THAT IS WRONG !!!
0.1 is the M.I. cutoff for TnT and NOT TnI !
I suspect that the 0.1 value may be the lowest claimed detectable for TnI
Read ALL the small print, not just the box.
I never trust what it says on the box : I keep seeing "Open Other End " - and it never is !
with best wishes
Richard
Richard Mainwaring-Burton
Consultant Biochemist
Queen Mary's Hospital
Sidcup, Kent
020-8308-3084
-----Original Message-----
From: Mohammad Al-Jubouri[mailto:[log in to unmask]]
Sent: 01 December 2008 15:05
To: [log in to unmask]
Subject: Re: Troponin I - quoted cut-off value 0.10 ug/L
I interpret it as any TnI value of 0.1 ug/L and above indicates myocardial damage, and any value < 0.1 ug/L does not indicate myocardial damage.
regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, FRCP Edin, FRCPath
Consultant Chemical Pathologist
________________________________
From:David Burgess <[log in to unmask]>
To: [log in to unmask]
Sent: Monday, 1 December, 2008 14:58:32
Subject: Troponin I - quoted cut-off value 0.10 ug/L
Please - how do you interpret the phrase, "Troponin I was analysed on an
Advia Centaur: quoted cut-off value 0.10 ug/L"
Regards, David.
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