It may well depend on the generation of assay in use. A limit of
detection of 0.1 ug/L seems a bit high for the new 2nd generation ultra
sensitive cTnI assay, but is possible for the original cTnI assay. The
ultra sensitive assay has a limit of detection of about 0.03 to 0.05
ug/L (sources vary). However, a cursory search suggests that 0.1 ug/L
has been used as a diagnostic threshold for cTnI, but I leave it to
others better placed to comment on how widespread this is - we do not
use the assay for diagnosis of MI.
Best wishes,
Dave
Dave
Dr David Hardy
Senior Scientist,
Regulatory Clinical Pathology, DSRD,
Pfizer Ltd,
Sandwich,
Kent CT13 9NJ
Tel: +44 (0)1304 640619
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of David Burgess
Sent: 01 December 2008 14:59
To: [log in to unmask]
Subject: Troponin I - quoted cut-off value 0.10 ug/L
Please - how do you interpret the phrase, "Troponin I was analysed on an
Advia Centaur: quoted cut-off value 0.10 ug/L"
Regards, David.
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