In the 'old' days (late'70s) we used to measure digitoxin using the digoxin immunoassay. That was in Guildford and if my memory serves me right, we used an in house method, where the antibody cross reacted to an extent with digitoxin (and other cardiac glycosides). Of course you had to use digitoxin standards, but it gave reasonable results. Of course the 'target' range for digitoxin is on a magnitude greater than that of digoxin, and of course it is less affected by renal function, since it is largely metabolised by the liver. Graham Graham Mould, PhD Consultant Pharmacist Direct Tel: +44 (0) 1483 684810 Fax: +44 (0) 1483 683481 Email: [log in to unmask] Surrey Technology Centre Surrey Research Park, Occam Road Guildford, Surrey GU2 7YG Please note my new telephone number. <http://www.gcpl.co.uk/> If you have difficulty in returning this email please try; [log in to unmask] _____ From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Frost, Stephen Sent: 18 December 2008 09:20 To: [log in to unmask] Subject: digitoxin Hi We have a patient on digitoxin with poor renal function, and the clinicians would like to measure the blood concentration. Do any of you have an assay for TDM digitoxin levels to which we could send samples, or know of one? Regards Steve (apologies for any duplication- have tried a few times to access mail-base) -----------------________________________________________________________ Dr Stephen Frost, MSc, PhD, FRCPath, MCB, CChem, MRSC Principal Clinical Scientist Department of Clinical Biochemistry and Immunology Brighton and Sussex University Hospitals NHS Trust The Princess Royal Hospital Lewes Road Haywards Heath West Sussex RH16 4EX Tel 01444 441881 ext 8197 Fax 01444 414051 email [log in to unmask] Views expressed are my own and not necessarily those of the Trust. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/