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Yes we had the exact same experience but we had for years believed it was always too high with many complaints from physicians. When we corrected it we sent them a letter explaining it was more in keeping with other methods and we now had a more standard reference range (in keeping with the literature) and we have a tagged addendum to each bilirubin result for 6 months stating that all values have dropped. Everyone is happy especially the Oncologists, the Infectious Disease and the GI guys. Elizabeth Mac Namara Montreal David Rambau wrote: > > Cobas 501 and Integra 400 calibrated to the new standard (Tbilirubin) > do not measure Total and Direct Bilirubin on equimolar basis. Our > set-points were dropped by 11% and 13% on Cobas 501 and Integra 400 > respectively. The difference beween the TBilirubin and DBilirubin > narrowed and at raised Tbilirubin concentrations, the measured > DBilirubin was greater than TBilirubin. Has anyone experienced this > with the re-standardization of the Roche TBilirubin? May you please > share your experience with me? > > > > I will welcome any positive contribution. > > > > ** ** > > ****************************************************************************************************************************** > > **Dr. PD Rambau** > > **Chemical Pathologist** > > **QA/Operational QC Division** > > **Lancet Laboratories (SANAS Accredited)** > > **Tel: +2711-3580800** > > **Fax: +2711-3580967** > > **e-mail**//: [log in to unmask] <mailto:[log in to unmask]>// > > **Web Address**//: http://www.lancet.co.za// > > *P** **Please protect our environment,do you really have to print this > e-mail?* > > > > > > *"This electronic communication (including attachments,) is from PD > Rambau, Lancet Laboratories, and is confidential, privileged and > intended only for the use of the recipient(s) named above. If you are > neither the intended recipient, the employee nor agent responsible > for delivering this information to the intended recipient(s), > unauthorized disclosure, copying, distribution or use of the contents > of this transmission is strictly prohibited. If you have received this > message in error, please return the material received to the sender > and delete all copies from your system." * > > * * > > * * > > * * > > > > > > ------ACB discussion List Information-------- This is an open > discussion list for the academic and clinical community working in > clinical biochemistry. Please note, archived messages are public and > can be viewed via the internet. Views expressed are those of the > individual and they are responsible for all message content. ACB Web > Site http://www.acb.org.uk List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List > Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/