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There is nothing possible via the user-interface, but if you can do a bit of basic MATLAB coding, then a slight tweek to the estimate function of spm_config_coreg.m (around line 280) from: x = spm_coreg(strvcat(job.ref), strvcat(job.source),job.eoptions); to: job.eoptions.params = [0 0 0 0 0 0 1 1 1 0 0 0] x = spm_coreg(strvcat(job.ref), strvcat(job.source),job.eoptions); should do the trick. I can't promise that it will work well though. Best regards, -John On Friday 31 October 2008 15:04, Stephen J. Fromm wrote: > I'm working out an analysis path for longitudinal VBM in rhesus monkeys > using SPM5. > > Because the earliest timepoint is at a juvenile stage, and the last is at > adult, I'm worried that SPM's coregistration routine (via the "Coregister" > button) won't be flexible enough, as it uses rigid body transforms only. > > Is there a way to do coreg in SPM using a more general affine > transformation? > > TIA, > > S