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Hi, For between subjects comparisons, would it make sense to evaluate the results of find_the_biggest as a ratio of [#voxels in seed mask for a given classification target]/[total #voxels in seed mask]? Preliminary data indicate some subjects differ in their weighting of # of seed mask voxels to each of three classification targets. For example, seed mask for subject A is 85% class1, 10% class2 and 5% class3 while that of subject B is 15% class1, 83% class2, and 2% class3. Is this approach reasonable? Or is there a better way? Any suggestions are greatly appreciated Jenifer