I'm new to this message system, so my apologies if this is posted twice. I am running TBSS on a large number of subjects (N = 75), everything works smoothly for the FA analysis, but I get the following error when I run TBSS_non_FA (MD): projecting all_MD onto mean FA skeleton /home/ssorg/fsl4/fsl/bin/tbss_non_FA: line 104: 7038 Killed ${FSLDIR}/bin/tbss_skeleton -i mean_FA -p $thresh mean_FA_skeleton_mask_dst ${FSLDIR}/data/standard/LowerCingulum_1mm all_FA all_${ALTIM}_sk eletonised -a all_$ALTIM So, it creates the all_MD image fine, but stops short of creating all_MD_skeletonized... bummer. I've noticed that the suggested solution is to get more ram or increase swap. I'm running on 2 gb of ram and 4gb of swap currently. I am wondering if there is an alternative solution? Is it possible to split the all_FA and all_MD 4D images into individual subject images and run tbss_skeleton for each subject in a loop and then merge the files to create all_MD_skeletonized? tbss_skeleton -i mean_FA.nii.gz 2000 mean_FA_skeleton_mask_dst.nii.gz ${FSLDIR}/data/standard/LowerCingulum_1mm all_FA0000.nii.gz MD_skeletonized_0000 -a all_MD0000.nii.gz I've seen this posted as a solution to memory shortages for generating the FA skeletons, but haven't seen it posted for non_FA.