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Hi, This isn't ideal, because SIENAX uses the (adult-based) MNI152 standard space image and associated brain mask for parts of its processing. Unless you have a suitable template that matches your age range I would recommend just using BET and then FAST to estimate the brain volume - see their manual pages in the FSL web pages. Cheers. On 31 Oct 2008, at 09:18, asaf achiron wrote: > Dear Group, > I am interested in measuring brain volume on neonatal MRI, > > Can i use sienax for this ? > > Thank you, > > Asa > > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------