Do you ever have experience with the diffraction quality of soft crystals? I just harvested some. They are 30K membrane protein, growing 10 months, size ~0.6mm*0.2mm*0.02mm, but as soft as a hair, no sharp surfaces.

We don't have synchrotron time in a few months and no experience with such crystals. Right now we need to decide whether we should use similar conditions for further screening or should change completely methods(from sitting drop to lipid cubic phase), and detergents. Any comments about your work with soft crystals are really helpful. Many thanks.