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Information that would be helpful: - version of CCP4 - Operating System/ Type of computer - exact error message (cut-and-paste) - file permissions (cf. James Stroud's answer) of the mtz-file in question - the output of 'which mtzdump' run both as user and as root Can you open a terminal, change to the particular directory where the mtz-file resides and type 'mtzdmp your-mtz-file.mtz'? Tim -- Tim Gruene Institut fuer anorganische Chemie Tammannstr. 4 D-37077 Goettingen GPG Key ID = A46BEE1A On Mon, 3 Nov 2008, luyongzhi99 wrote: > Hi, every one, when I run refmac in the ccp4,it gives an warning: CCP4i encountered an error when to extract the data from .mtz file. But in the root account, it is OK. > Thanks! > >