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Dear SPM'ers, I was brought the following PET design, 1 FDG scan per condition, 2 groups, 2 conditions. The researchers want to do a group x condition comparison. The following is the design matrix used: [cid:image001.jpg@01C9303F.35285B80] SPM5 errors out during the ReML estimation of covariance components. The error is as follows. [cid:image002.jpg@01C9303F.35285B80] I stepped through the code and it appears the design matrix size changes during the orthogonalization of the matrix in the spm_reml.m preventing the matrix multiplication. Anyone know what this in fact means from an SPM perspective? What do I need to do in order to "fix" this design? I've tried different numbers of subjects but to no avail. Thanks! Dave Keator UC Irvine ________________________________ This message contains confidential information and is intended only for the individual named. If you are not the named addressee you should not disseminate, distribute or copy this e-mail. Please notify the sender immediately by e-mail if you have received this e-mail by mistake and delete this e-mail from your system. E-mail transmission cannot be guaranteed to be secure or error-free as information could be intercepted, corrupted, lost, destroyed, arrive late or incomplete, or contain viruses. The sender therefore does not accept liability for any errors or omissions in the contents of this message, which arise as a result of e-mail transmission.