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Hi, Hard to quantify to be sure on this - but I would have thought that a well-spaced set of 21 directions should not make too much difference if the exact locations of the bvecs are changed a little between different acquisitions - Tim or Saad can comment further if they disagree. Cheers. On 9 Oct 2008, at 15:28, Jenifer Juranek wrote: > Thanks, Steve. > Could you help me understand "reasonably large"? > Data has 21 directions (and a single b0). > Reasonable to pool data across bvec variants? > Interested in both quantitative metrics (FA, MD) and probabilistic > tractography (in case definition of reasonably large varies by > objective). > > Jenifer > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------