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Dear Juergen, Sounds like ReML didn't converge. If there was 128 iterations before the display of the error message, that was indeed the case. You might then want to change the option "Variance" to "Equal" in your paired t-test and try to estimate your model again. Best regards, Guillaume. Juergen Haenggi wrote: > Dear SPM experts > > I tried to do an paired t-test with SPM5 (Upd 1782), but the following error > occurred: > > Error running job: Output argument "V" (and maybe others) not assigned > during call to "/Applications/MATLAB74/work/spm5_upd1782/spm_reml.m > (spm_reml)". > In file "/Applications/MATLAB74/work/spm5_upd1782/spm_spm.m" (v946), > function "spm_spm" at line 907. > In file "/Applications/MATLAB74/work/spm5_upd1782/spm_config_fmri_est.m" > (v832), function "run_est" at line 394. > > What does it mean? > > Thanks in advance > Best regards > Juergen -- Guillaume Flandin, PhD Wellcome Trust Centre for Neuroimaging University College London 12 Queen Square London WC1N 3BG