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Hi Vincent > Dear SPMers, > I got an error as follows in one session of one subject, > ??? Error using ==> spm_spm at 861 > Please check your data: There are no significant voxels. > But I have no idea what is wrong with my data or any settings? > Any comments are greatly appreciated. no matlab problem here, this is an SPM feature - if I am right your analysis did run well (i.e. you got spm beta files generated) but at the end of it you got this message .. spm_spm checks if you have some significant voxel for an omnibus F test but apparently you don't .. thus the error message meaning that no voxel have an activity > mean for any combination of your regressors - if think SPM setting are ok if other subjects were fine ; must be the data ... cyril -- The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.