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You are supposed to be able to do this as described in the help for spm_write_sn.m - but you will need to do a bit of scripting yourself. If you are using 3rd party software for this editing, please make sure that it is NIfTI compatible. If it isn't, then things are unlikely to work. Best regards, -John On Monday 22 September 2008 16:13, John wrote: > VBM question: > > We are finding some skull in our segmented images and would like to be > able to manually edit the gray matter images prior to modulation. How > do we call the modulation routine once we finish the editing? > > Thank you in advance for any assistance, > John