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What value do we expect for the pKa of a protein's C-terminal carboxylate? pKa values for free amino acids are quite low (2-3), but it seems to me that this may have something to do with the proximity of a free amine group; I'd expect a higher value (4-ish?) for the peptide's C-terminus. A quick & lazy search using the term "pka" was stymied by a gazillion references to protein kinase A... Thanks, Pat ------------------------------------------------------------------------ --------------- Patrick J. Loll, Ph. D. Professor of Biochemistry & Molecular Biology Director, Biochemistry Graduate Program Drexel University College of Medicine Room 10-102 New College Building 245 N. 15th St., Mailstop 497 Philadelphia, PA 19102-1192 USA (215) 762-7706 [log in to unmask]