I would auggest that myocardial damage can be associated with rhabdomyolysis of varying aetiology and certainly it has been described with ecstacy induced rhabdomyolysis.
Best regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, FRCP Edin, FRCPath
Consultant Chemical Pathologist
----- Original Message ----
From: "Metz, Michael (CYWHS)" <[log in to unmask]>
To: [log in to unmask]
Sent: Friday, 26 September, 2008 4:38:45
Subject: TnT in rhabdomyolysis
TnT in rhabdomyolysis
We recently attended a wel grown 15 year old girl who presented with a Glascow Coma Scale score of 3 after an evening of bourbon and ecstasy (MDMA or Methylenedioxymethamphetamine) ingestion. The ecstasy was stronger than usual.
She developed rhabdomyolysis with CKs of 100,000 U/L. She also developed some renal embarassment with creatinine to 190 umol/L and some hepatic injury as well.
She is good now. Laughing and joking.
My question has to do with a Troponin T (NR: <0.03) of 0.15 ug/L obtained at about 60 hours while the CK was still 60,000 U/L. No myoglobin measured.
She has had no evidence of cardiac injury by rhythm, ECG, symptoms, or physical signs. No cardiac ultrasound undertaken.
I expect that all of this TnT is skeletal TnT not cardiac TnT. What do you reckon?
Thanks.
Michael P Metz
BS, MD, FAAP, MAACB, FRCPA
Chemical Pathologist
Division of Laboratory Medicine
Women's & Children's Hospital
72 King William Road
North Adelaide, South Australia
5006
phone: 08 8161 7483
mobile: 0421 098 430
e-mail: [log in to unmask]
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
