Dear Meg,
2. When SPM prompts you
"FWE", "FDR", and "none", choose "none"
and try 0.001 (or 0.01, 0.005 etc). If you choose "FWE" p<0.05,
then SPM uses an FWE-corrected threshold at the VOXEL-LEVEL, which is often
creates spurious results on cluster p-values. The corrected cluster p-values
are FWE corrected, even if you choose "none", or an uncorrected
threshold. Cluster p-values are adaptive, meaning that they are adjusted for
the threshold chosen by the user.
I'm not clear on exactly what is being said
here. Say i choose "none" and set my level to 0.001. You
say that the "cluster p-values are FWE corrected even if I choose
"none" ? Is that true? Does this mean I don't need to do
any further corrections?
You are correct. The three options SPM
gives, “FWE”, “FDR”, and “none” (or uncorrected)
only apply to voxel-level p-values. Although the threshold you choose is taken
into account, cluster p-values are calculated differently from voxel-level
p-values. So the “Corrected” p-values for the cluster-level in your
SPM output are already corrected for FWE, if you are doing PET, SPECT, or fMRI
analyses. In VBM, cluster p-values need an additional correction, as I noted in
my email earlier.
Hope this helps.
-Satoru