Shivesh If you have not already, maybe try the following: 1. Adding other alcohols as an additive. See work by Keichi Namba in improving his flagella crystals. The idea is to poison growth in one direction. I have also had success in "thickening" crystals grown in MPD, by addition of 1-3% isopropanol... 2. Other alcohols as the precipitant. 3. Streak seeding. 4. Lower temperature. Maybe nucleation at RT and then slow cool to four degrees C. Daniel > Dear all, > I am trying to improve the quality of a xtal, crystallizing with MPD as a > precipitant at 16 degree C with thin plate like xtals. I would appreciate > suggestions to have diffraction quality xtals (thick). I am using proline, > glycine, glucose, sucrose as an additive.Thanx in advance. > shivesh >