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Dear All, Can anyone teach me how to refine a ligand in a protein structure with half occupancy in refmac? I have tried to combine the coordinates of the two different conformations of that particular ligand in one pdb, after modeling in Coot individually, and then changed the occupancy to 0.5 for each of the conformation. However, I couldn't manage to refine this pdb in Refmac. Thanks in advance! Best regards, Matt ---------------------------------------------------------------------------- Matthew LH Chu PhD Student School of Pharmacy and Pharmaceutical Sciences University of Manchester ----------------------------------------------------------------------------