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Dear colleagues, I have a structure with two identical dimers per asymmetric unit. If the dimers are identical in different crystalline environments and in different crystal forms they should be particularly stable. How does such a stable dimer crystallize? Is it necessay to pre-exist in the specific conformation in solution (even to a lesser extent than a major monomeric form) or a very stable dimer can assemble from the very beginning durnig crystallization? And can the same dimer form during crystallization in different crystalline environments without it being present in solution to any (even infinitesimal) extent? I would appreciate all responses. Thanks. Mike Colaneri