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Phillipp, Good answer to that question - to follow up - if you did modulate and thus the values can be interpreted as volumes, what are the units of those volumes? ml? mm cubed? Cyrus ________________________________________ From: SPM (Statistical Parametric Mapping) [[log in to unmask]] On Behalf Of Philipp G. Sämann [[log in to unmask]] Sent: Friday, April 04, 2008 11:18 AM To: [log in to unmask] Subject: Re: [SPM] extract voxel value in VBM date Hello Beate, I have not followed the mail exchange on your question so far, so hopefully this is not redundant. As you write, you can extract 'raw data' from the smoothed images by the V. O. I. function, e. g. for one voxel (radius 0 mm) or some other shape. The meaning of these values depends of your preprocessing: I assume, your data have undergone the Jacobian modulation step that is generally recommended for VBM - multiple postings exist on this issue. If you had switched on this step during the normalisation or segmentation step, the values extracted can be interpreted as volumes and can therefore be treated like that in an offline statistics. Depending on what your question is, you would then probably also have to include appropriate covariates, including total grey (or white) matter, gender, age or others. If you had not switched on the modulation step and selected 'preserve concentration' instead of 'preserve volume', the interpretation of the local value is indeed a different one, rather a probability of that voxel to be GM. Does this answer the question? best regards, Philipp