 |
 |
Hi Silke > > Dear SPM users, > > I have compared gray matter volumes of MCI patients with that of > healthy controls using SPM5 (voxel based morphometry). > > The MCI patients show grey matter loss in some regions important for > episodic memory retrieval. > > Now I would like investigate, whether there is a correlation between > the performance in word list recall and grey matter loss. > > Is there a way to do such an analysis in SPM5? If the answer is yes – > how does it work? Is there any users guide explaining the steps (since > I am not a very experienced SPM user)? > Well using the multiple regression design could for instance not only test the difference between groups (regressor 1 and -1 for control / MCI - simply test with 1 in the contrast manager) but also the correlation within each group and between groups (regressor xxxx0000 for controls for instance and 0000xxxx for MCI - then 10 = correlation in controls, 01 correlation in MCI and 1-1 controls>MCI). For more information on VBM and possible things to look at I would suggest first looking at the VBM5 toolbox http://dbm.neuro.uni-jena.de/vbm/vbm5-for-spm5/ Best Cyril -- The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.