Hi, I would like to double-check a couple of things: 1. After randomise on TBSS data (a simple group comparison with two contrast 1 -1 and -1 1), if I consider this as a 2-tailed test in displaying the result of p-values (eg. Maxc_tstat) I view it as 0.975-1 (if the p-value I want is p<0.05). Is it correct? 2. Demeaning the values in randomise: There are two options: - to add an additional EV (with "1" only) and add -D in the command line - to enter already demeaned values into the design. Is it correct? 3. What will really happen if I don't demean my data (in case I should)? 4. Is the design below correct for the correlation of TBSS data with 1 EV of some demeaned parameter x? Should I run it with -D or without? /ContrastName1 x /NumWaves 1 /NumContrasts 1 /PPheights 6.651000e+03 /RequiredEffect 5.308 /Matrix 1.000000e+00 /NumWaves 1 /NumPoints 17 /PPheights 6.651000e+03 /Matrix -1.492000e+03 5.159000e+03 8.620000e+02 -1.361000e+03 -9.570000e+02 -1.162000e+03 -1.444000e+03 6.610000e+02 -4.190000e+02 -9.280000e+02 -1.287000e+03 3.091000e+03 2.097000e+03 -1.013000e+03 -1.038000e+03 -6.870000e+02 -7.600000e+01 5. Is this a correct design for correlation of TBSS data with parameter x, with parameter y as a covariate ("controlling for y")? Do I enter other parameters in randomise as before (eg. t-value threshold, etc.?) /NumWaves 2 /NumPoints 17 /PPheights 6.651000e+03 8.000000e+00 /Matrix -1.492000e+03 0.000000e+00 5.159000e+03 1.000000e+00 8.620000e+02 -4.000000e+00 -1.361000e+03 -4.000000e+00 -9.570000e+02 0.000000e+00 -1.162000e+03 -1.000000e+00 -1.444000e+03 0.000000e+00 6.610000e+02 -1.000000e+00 -4.190000e+02 0.000000e+00 -9.280000e+02 0.000000e+00 -1.287000e+03 2.000000e+00 3.091000e+03 -2.000000e+00 2.097000e+03 -1.000000e+00 -1.013000e+03 4.000000e+00 -1.038000e+03 -1.000000e+00 -6.870000e+02 2.000000e+00 /ContrastName1 x /ContrastName2 y /ContrastName3 x(y) /NumWaves 2 /NumContrasts 3 /PPheights 7.017095e+03 8.046171e+00 8.045551e+00 /RequiredEffect 5.870 5.827 5.827 /Matrix 1.000000e+00 0.000000e+00 0.000000e+00 1.000000e+00 1.000000e+00 1.000000e+00 -7.600000e+01 -3.000000e+00 6. What is the minimum of subjects one needs to perform a decent correlation analysis in such case? 7. Is it possible to perform a hierarchical multiple regression in glm? I will be very grateful for your advice. Best, Aga