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This appears to be the unfortunate, but inevitable result of the membrane protein structure retractions from 2007. Without a doubt, there needs to be at least one crystallographer reviewing the structures for structure papers, as any crystallographer would be comfortable with the claims that Jim is making from the 3.45A structure that is properly restrained and refined. Kevin P Madauss V-161a US Structural Biology GlaxoSmithKline Office: 919.483.3759 5 Moore Drive Cell: 919.924.6436 RTP, NC 27709