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Dear Colleagues I have been asked by our Consultant Clinical Toxicologist if anyone can provide a service for toxic alcohols including ethylene glycol both within normal laboratory working and out of hours for urgent cases. This is to cover the period while the Medical Toxicology Laboratory (MTL) relocates from their current site to St Thomas Hospital, the requirements are indicated below. For samples taken from patients within our own Trust the closer to London the laboratory is the better, although we can courier samples elsewhere. * Currently we are managing 2-3 patients per week with most of these patients needing toxic alcohol screening to be undertaken on 2 or 3 consecutive days. Most of these patients are being managed in other hospitals and the samples are couriered directly to MTL from the ICU rather than through the local biochemistry laboratory. regards Beverley Beverley Earl Governance Manager Specialised Laboratory Medicine 5th Floor North Wing St Thomas' Hospital Lambeth Palace Road London SE1 7EH tel: 02071880084 ________________________________ From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of IAN WATSON Sent: 16 April 2008 09:29 To: [log in to unmask] Subject: Re: ethylene glycol We had 3 cases in the NW at that time too. I've collated the data from the questions I asked about availability of EtGly & MeOH analysis and am in discussion with NPIS. Ian Dr Ian D Watson Consultant Biochemist & Toxicologist Dept Clinical Biochemistry University Hospital Aintree Lower Lane Liverpool L9 7AL Tel +44 151 529 3575 Fax +44 151 529 3310 ________________________________ From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Colley, Michael Sent: 15 April 2008 15:39 To: [log in to unmask] Subject: Re: ethylene glycol I posted this on the Mail list on 4th February, just a couple of days after the news hit the papers. Guys told me they'd seen a major surge in numbers over the few days after that. I'm please to say we haven't had another...yet. Michael ------------------------------------------------------------------------ ----------------------------- Further to Jonathan Kay's email re. the "Antifreeze" case, I'm delighted to report that our first Ethylene Glycol overdose for many years presented at 10:30 on Thursday morning. Despite having apparently drunk about 700 ml of it he seems to be reasonably well at present. He had an osmolar gap of well over 20 mosmol/L and his Glycol level was 2g/L. Dialysis is recommended at >0.5 g/l. However, as he appeared well, dialysis was not carried out and he was treated with fomepizole. Appears to have survived very well and was transferred from ICU to the ward yesterday. Will keep you updated if anything further of interest arises. How many people do EtOH levels by a non-GC (i.e. enzymatic) method? As we don't it couldn't be monitored regularly which is why he received fomepizole rather than EtOH infusion. Michael ============================================================= ________________________________ Swindon & Marlborough NHS Trust Great Western Hospital Marlborough Road Swindon SN3 6BB Tel 01793 60 40 20 http://www.swindon-marlborough.nhs.uk This message and any files transmitted with it are confidential and intended solely for the individual(s) addressed. 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