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Dear all, I am using SPM5 to perform a VBM analysis. In order to maximise the quality of the segmentation step, and to maintain consistency with data pre-processing, I am considering manually reorienting all my images to be perfectly aligned to the grey matter tissue probability map (as far as human subjectivity allows) using the 'check reg' function. Having looked at images in both cases - non-reoriented v oriented, the segmentation result appears visually very similar, however, this cannot be equated with absolute accuracy, and clearly, I would like to get the very best out of my data-set. Given the large volume of images I will be working with(>150), I would like to know if this is a methodologically robust and sensible approach to pre-processing the data i.e. would the improvement in segmentation be significant enough to impact on data quality and hence the final outcome of the statistical analysis? Many thanks for your advice, Kind regards, Louise Emsell Clinical Neuroimaging Lab Dept Psychiatry NUI Galway [log in to unmask]