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Yes, thanks for the answer, now that I think of it it was a pretty silly question, but I just was following the directions in the randomise webpage without really understanding the background... Stefano ________________________________ From: Reza Salimi [mailto:[log in to unmask]] Sent: Thursday, March 27, 2008 1:49 PM To: [log in to unmask] Subject: Re: [FSL] tfce through fslmaths Hi Stefano, I can't clearly understand your question, but think this might be the answer you are looking for TFCE image is not like z_stat image for which you have a default null distribution, so you need to have your null distribution generated and do a (voxel-wise) non-parametric test to assess the statistical significance of your image, one way of doing it is to use randomise and making the distribution of max_tfce over each fake image and then calculating the p-value for each voxel in your observed (real) image, Best, Reza On Thu, Mar 27, 2008 at 5:30 PM, Marenco, Stefano (NIH/NIMH) [E] <[log in to unmask]> wrote: I got an image of the tfce statistic with fslmaths. How do I transform this to a p value image (from tfce_tstat to _max_tfce_tstat)? Stefano Marenco, MD NIMH/GCAP Building 10, room 4S235 10 Center Drive Bethesda, MD 20892 tel 301 435-8964 fax 301 480-7795 email: [log in to unmask] <mailto:[log in to unmask]> -- G. Salimi-Khorshidi, DPhil Student in Oxford Centre for Functional MRI of the Brain (FMRIB) Dept of Clinical Neurology, University of Oxford webpage : http://bme.aut.ac.ir/~gsalimi <http://bme.aut.ac.ir/%7Egsalimi> email : [log in to unmask]