Aga, Unfortunatly, I don't think automated processing will be possible with this dataset. The only workable approach to do automated HWM lesion segmentation is by the use of T2-maps produced by the multi-echo sequences. pk ----- Original Message ----- From: "Agnieszka Burzynska" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, March 18, 2008 7:09 AM Subject: [FSL] White matter hyperintensity and FLAIR processing > Dear all, > I am searching for the most straightforward way to estimate the WMH load > in > my subjects. > 1) Was there any follow-up on the message from 2002? (see below) > 2) My FLAIR images have resolution 1.3x0.9x5mm and my MPRAGE 2x2x1mm. Does > it mean I will have hard time in registering them to MNI? > > Thank you! > > Aga > > > On Mon, 22 Jul 2002, Wei Wen wrote: > >> Dear Steve, >> >> It may be possible to extract (segment) white matter hyperintensity >> (FLAIR >> sequence) using a combination of bet, fast etc. as discussed at FSL >> course >> in Melbourne. Could I send you a couple of such images and see if you >> could >> tweak the programs (or come up with some suggestions) for this purpose? >> >> Many thanks, >> >> Wei Wen >> NPI, Prince of Wales Hospital/UNSW >> Australia >> >> >