Hi all,

I would like to generate a structure-based multiple sequence alignment
using 4 structures.  I have already generated pairwise alignments for
each 'pair' of structures (6 alignments in all).  Is there a program
out there that can take a number of aligned structures (or even just a
number of pairwise sequence alignments) and calculate the 'best'
multiple sequence alignment?  Please note that there is absolutely no
sequence conservation between these structures, making standard
sequence-based alignment tools pretty useless.

Thanks,

Stephen

--
Dr Stephen Graham
Nuffield Medical Fellow
Division of Structural Biology
Wellcome Trust Centre for Human Genetics
Roosevelt Drive
Oxford OX3 7BN
United Kingdom
Phone: +44 1865 287 549