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Our paper describes why PTH is not a good index of vitamin D status Patel S, Hyer S, Barron J 2007 Glomerular filtration rate is a major determinant of the relationship between 25-hydroxyvitamin D and parathyroid hormone Calcified Tissue International.80, 221-226. Jeff Dr Jeffrey Barron Consultant Chemical Pathologist Director SW Thames Regional Newborn Screening St Helier Hospital Carshalton Surrey SM5 1AA UK Tel UK 20 8296 2660 Fax UK 20 8641 2633 [log in to unmask] >>> Victoria Clough <[log in to unmask]> 03/17/08 1:30 pm >>> We have noticed a significant increase in the number of requests we are receiving for 25OHD and are trying to establish whether it is always necessary to measure 25OHD itself or if PTH can be used as a first line test, with 25OHD being measured only if the PTH is raised. I've come across a couple of papers which recommend the above approach but have also read several which suggest that PTH is no substitute for 25OHD as it can be normal in vitamin D deficiency and shows poor correlation with 25OHD, with the relationship between the 2 analytes varying with age. It would be useful to know the approach taken by other labs and I'd be grateful for any references which decisions have been based on. Thank you Victoria Clough Pre-Registration Clinical Biochemist King George Hospital, Goodmayes ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/