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Hong,

>If approximate inference is sufficient, and you know at least the FHWM of >the noise smoothness, the snippet below will give you some idea of the >corrected P-value for a given FWHM, assuming a spherical search region of a >given radius. 

Is there a program in SPM can be used to estimate the FWHM of the noise smoothness, if I provide the noise images?

Yes, see spm_est_smoothness.m, which uses residual images to estimate smoothness.

-Tom



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Thomas Nichols, PhD
Director, Modelling & Genetics
GlaxoSmithKline Clinical Imaging Centre

Senior Research Fellow
Oxford University FMRIB Centre