Ian,

CSF ferritin is massively raised in siderosis. We use a reference range of <12 ug/L derived from CSF obtained from patients in our institution where no pathology had been demonstrated.

Ian

Dr Ian D Watson

Consultant Biochemist

Dept Clinical Neurobiochemistry

The Walton Centre for Neurology & Neurosurgery

Lower Lane

Liverpool

L9 7LJ

Tel +44 151 529 3575 (office)

+44 151 529 5577 (lab)

Fax +44 151 529 3310

From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Woodrow Iain
Sent: 06 February 2008 12:35
To: [log in to unmask]
Subject: CSF ferritin and iron for superficial siderosis

Hi all,

Does anyone have any experience in measuring ferritin and iron in CSF to investigate for superficial siderosis? We have a request for this in a patient who has an apparently equivocal MRI scan, with a previous history of surgical brain procedures (a predisposing factor). I can find very little about it in an, albeit brief, literature search, though one paper from presented two cases where the CSF ferritin was greatly elevated (values of 90 and 31 respectively, with a reference range of <12ug/L, though no indication from where this was derived).

I have tried Sheffield and Leeds in our locale, plus Queen’s Sq in London.

Thanks in anticipation,

Iain Woodrow

Dr I Woodrow,

Clinical Scientist,

Pinderfields Hospital,

Wakefield

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